简介：

      杨涛，男，1969年出生，江苏省徐州市人，主任医师、教授、博士生导师，教授、主任医师、博士生导师。主要研究方向为1型糖尿病免疫治疗和胰岛移植，主持国家自然科学基金重点项目、面上项目等共5项、“973”前期研究计划1项，发表SCI文章60余篇。2012年获中国医师协会内分泌代谢医师奖。

现任职务：

      南京医科大学第一附属医院内分泌科主任，江苏省人类功能基因组学重点实验室副主任

专业方向：

      内分泌代谢病

科研方向：

      1型糖尿病免疫机制和免疫治疗，胰岛移植，甲状腺自身免疫病

主要学术兼职：

      中华医学会糖尿病学分会委员，胰岛Beta细胞学组组长(筹)；中华医学会内分泌学分会委员，肥胖学组副组长；中国胰岛素分泌研究小组，副组长；江苏省医学会内分泌学分会，副主任委员；南京市医学会内分泌学分会，主任委员；全国高等学校五年制本科教材《内科学》(第8版)编委；《中华内分泌代谢杂志》、《中华糖尿病杂志》、《中国糖尿病杂志》编委

近年承担课题

1、定制化T细胞表位疫苗免疫治疗1型糖尿病研究，国家自然科学基金重点项目，2016.1-2020.12，343万元，第一负责人。

2、应用HLA-A2.1限制性T细胞表位库探索1型糖尿病特异性多靶点细胞免疫治疗的研究，国家自然科学基金，2013.1-2016.12，120万元，第一负责人。

3、糖尿病诊疗新方案和新技术的研究与推广，江苏省临床医学科技专项， 2012.7-2015.7，200万元，第一负责人。

4. 沙格列汀对1型糖尿病血糖波动和免疫调节作用的研究，国际协作项目，100万，2015.6-2016.6，项目负责人。

5. DPP-4抑制剂限制糖尿病小鼠再狭窄倾向血管增生过程的研究，国际协作项目，10.5万，2015.01-2017.12，项目负责人。

6. 1型糖尿病疾病管理和控制与妊娠结局关系的研究，卫计委公益性行业科研专项，35万，分项目负责人。

7、胰岛特异性锌转运体-8在自身免疫糖尿病发病机制中的作用，973计划前期研究专项(重大疾病防治新方法研究)，2011.1－2013.12，59万元，第一负责人。

8、特异性胰岛自身抗原ZnT8的HLA限制性T细胞抗原表位研究，国家自然科学基金，2010.1－2012.12，32万元，第一负责人。

9、社区人群代谢综合征的综合早期综合干预对社区代谢综合征人群胰岛功能的影响，江苏省科技支撑计划(社会发展)重点项目，2010.1－2012.12，30万元，第一负责人。

代表性论文（或近五年文章）：

1.Liu X, Zhu L, Wang Z, Cui D, Chen H, Duan Y, Shen M, Lu H, Zhang Z, Chen J, Alexander EK, Yang T, Wang X. Evolutionary features of thyroid cancer in patients with thyroidectomies from 2008 to 2013 in China. Sci Rep. 2016,6:28414.

2.Liu J, Bian L, Ji L, Chen Y, Chen H, Gu Y, Ma B, Gu W, Xu X, Shi Y, Wang J, Zhu D, Sun Z, Ma J, Jin H, Shi X, Miao H, Xin B, Zhu Y, Zhang Z, Bu R, Xu L, Shi G, Tang W, Li W, Zhou D, Liang J, Cheng X, Shi B, Dong J, Hu J, Fang C, Zhong S, Yu W, Lu W, Wu C, Qian L, Yu J, Gao J, Fei X, Zhang Q, Wang X, Cui S, Cheng J, Xu N, Wang G, Han G, Xu C, Xie Y, An M, Zhang W, Wang Z, Cai Y, Fu Q, Fu Y, Zheng S, Yang F, Hu Q, Dai H, Jin Y, Zhang Z, Xu K, Li Y, Shen J, Zhou H, He W, Zheng X, Han X, Yu L, She J, Zhang M, Yang T. The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients. Sci China Life Sci. 2016 May 25. [Epub ahead of print]

3.Xu K, Jiang L, Zhang M, Zheng X, Gu Y, Wang Z, Cai Y, Dai H, Shi Y, Zheng S, Chen Y, Ji L, Xu X, Chen H, Sun M, Yang T. Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals. Medicine (Baltimore). 2016 May;95(19):e3604.

4.Xiaoyun Liu, Yun Cai, Zhixiao Wang, Dai Cui, Hongqi Fan, Lin Jiang, Huanhuan Chen, Ling Wei, Qing Yao, Yunsong Wu, Rong Rong, Zhihong Zhang, Edmund S Cibas, Erik K Alexander, Tao Yang, Xiaodong Wang: Adequacy rate comparison between liquid-based cytology using SurePath versus conventional smears in detecting thyroid malignancies. Int J Clin Exp Pathol 2016;9(4):4448-4454.

5.Wang J, Zheng X, Sun M, Wang Z, Fu Q, Shi Y, Cao M, Zhu Z, Meng C, Mao J, Yang F, Huang X, Xu J, Zhou H, Duan Y, He W, Zhang M, Yang T; REACTION Study Group.Low serum free thyroxine concentrations associate with increased arterial stiffness in euthyroid subjects: a population-based cross-sectional study.Endocrine. 2015, 50:465-73.

6.Liu XY,Zhu LJ,Wang ZX,Cui D,Chen HH,Wei L,Wu YS,Rong R,Wu Y,Yao Q,Zhang ZH,Cibas ES,Alexander EK,Yang T.Comparison of two different standards of care in detecting malignant thyroid nodules using thyroid fine-needle aspiration,Mol Clin Oncol,2015,3:682-6.

7.Wang GF, Yan YX, Xu N, Yin D, Hui Y, Zhang JP, Han GJ, Ma N, Wu Y, Xu JZ, Yang T. Predictive Factors of Type 2 Diabetes Mellitus Remission Following Bariatric Surgery: a Meta-analysis.Obes Surg,2015,25(2):199-208.

8.Liu X, Zhu L, Cui D, Wang Z, Chen H, Duan Y, Shen M, Wu Y, Rong R, Zhang Z, Wang X, Chen J, Alexander EK, Yang T.Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort. Int J Endocrinol. 2014;2014:769294.

9.Chen H, Zhang M, Wang Y, Yu X, Gu Y, Xu X, Xu K, Cai Y, Sun M, Zhou H, Yang T.Islet neogenesis-associated protein-related pentadecapeptide improves the function of allograft after islets transplantation.J Pediatr Endocrinol Metab.2014, 27(11-12):1167-73.

10.Shi Y, Sun M, Wang Z, Fu Q, Cao M, Zhu Z, Meng C, Mao J, Duan Y, Tang W, Huang X, Lu J, Bi Y, Ning G, He W, Yang T.Association between calcaneus quantitative ultrasound (QUS) parameters and thyroid status in middle-aged and elderly Chinese men with euthyroidism: a population-based cross-sectional study. Endocrine. 2014,47(1):227-33.

11.Liu XY, Zhu LJ, Cui D, Wang ZX, Chen HH, Duan Y, Shen MP, Zhang ZH, Wang XD, Chen JW, Alexander EK, Yang T. Annual financial impact of thyroidectomies for nodular thyroid disease in china. Asian Pac J Cancer Prev. 2014;15(14):5921-6.

12.Yang F,Wang G,Wang Z,Sun M,Cao M,Zhu Z,Fu Q,Mao J,Shi Y,Yang T. Visceral adiposity index may be a surrogate marker for the assessment of the effects of obesity on arterial stiffness. PLoS One. 2014;9(8):e104365.

13.Tang W, Fu Q, Zhang Q, Sun M, Gao Y, Liu X, Qian L, Shan S, Yang T.The Association between Serum Uric Acid and Residual β -Cell Function in Type 2 Diabetes. J Diabetes Res. 2014;2014:709691.

14.Xu X,Zheng S,Yang F,Shi Y,Gu Y,Chen H,Zhang M,Yang T. Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes.Endocrine. 2014,46(1):90-98.

15.Fu Q,Sun M,Tang W,Wang Z,Cao M,Zhu Z,Lu L,Bi Y,Ning G,Yang T. A Chinese risk score model for identifying postprandial hyperglycemia without oral glucose tolerance test. Diabetes Metab Res Rev. 2014, 30(4):284-90.

16.Wang G, Zhang Q, Xu N, Xu K, Wang J, He W, Yang T. Associations between Two Polymorphisms (FokI and BsmI) of Vitamin D Receptor Gene and Type 1 Diabetes Mellitus in Asian Population: A Meta-Analysis.PLoS One. 2014, 9(3):e89325.

17.Guo H, Sun M, He W, Chen H, Li W, Tang J, Tang W, Lu J, Bi Y, Ning G, Yang T, Duan Y. The prevalence of thyroid nodules and its relationship with metabolic parameters in a Chinese community-based population aged over 40 years. Endocrine. 2014,45(2):230-5.

18.Sun M, Cao M, Fu Q, Zhu Z, Meng C, Mao J, Shi Y, Duan Y, Tang W, Huang X, He W, Yang T.Association of calcaneal quantitative ultrasound parameters with metabolic syndrome in middle-aged and elderly Chinese: a large population-based cross-sectional study. BMC Endocr Disord. 2014, 14(1):14.

19.Zhang Q, Wang Z, Sun M, Cao M, Zhu Z, Fu Q, Gao Y, Mao J, Li Y, Shi Y, Yang F, Zheng S, Tang W, Duan Y, Huang X, He W, Yang T. Association of high vitamin d status with low circulating thyroid-stimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. Int J Endocrinol. 2014, 2014:631819.

20.Xu K,Liu X,Yang F,Cui D,Shi Y,Shen C,Tang W,Yang T. PAI-1 -675 4G/5G polymorphism in association with diabetes and diabetic complications. PLoS One. 2013,8(11):e79150.

21.Xu X,Shi Y,Cai Y,Zhang Q,Yang F,Chen H,Gu Y,Zhang M,Yu L,Yang T. Inhibition of increased circulating Tfh cell by anti-CD20 monoclonal antibody in patients with type 1 diabetes. PLoS One. 2013;8(11):e79858.

22.Fan HQ, Tang W, Wang ZX, Wang SJ, Qin YH, Fu Q, Gao Y, Sun M, Zhang M, Zhou HW, Yang T: Association of Serum Uric Acid with 2-Hour Postload Glucose in Chinese with Impaired Fasting Plasma Glucose and/or HbA1c. PLoS One 2013,8(7):e67759

23.Meng CC, Sun M, Wang ZX, Fu Q, Cao MD, Zhu ZX, Mao J, Shi Y, Tang W, Huang XP, Duan Y, Yang T, Insulin sensitivity and beta-cell function are associated with arterial stiffness in individuals without hypertension. J Diabetes Res. 2013;2013:151675.

24.Kong LL,Cai Y,Mei G,Gu R,Zhang XJ,Qin Y,Cai Y,Li Y,Zhou HW,Zhang M,Yang T,Psychological status and diabetes-related distress of Chinese type 1 diabetes patients in Jiangsu Province. J Biomed Res, 2013, 27(5):380-85.

25.Qian L, Xu KF, Xu XY, Gu R, Liu X, Shan S, Yang T, UCP2-866G/A, Ala55Val and UCP3-55C/T Polymorphisms in Association with Obesity Susceptibility -A Meta-Analysis Study. PLoS One. 2013,8(4):e58939.

26.Guo J, Ren W, Li A, Ding Y, Guo W, Su D, Hu C, Xu K, Chen H, Xu X, Yang T, Jia W. Fat Mass and Obesity-Associated Gene Enhances Oxidative Stress and Lipogenesis in Nonalcoholic Fatty Liver Disease. Dig Dis Sci. 2013,58(4):1004-9.

27.Guo J, Ren W, Ding Y, Li A, Jia L, Su D, et al. Fat Mass and Obesity Associated Gene (FTO) Expression Is Regulated Negatively by the Transcription Factor Foxa2. PLoS One. 2012;7(12):e51082.

28.Zha M, Zhang M, Shan S, Xu KF, Chen H, Xu XY, Qian L, Han X, Yang T.Effects of islet neogenesis-associated protein pentadecapeptide on cell mass and insulin secretion of pancreatic β-cells. J Endocrinol Invest. 2012,35(7),634-9.

29.Yang H, Wang Z, Xu K, Gu R, Chen H, Yu D, Xing C, Liu Y, Yu L, Hutton J, Eisenbarth G, Yang T. IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population.Autoimmunity. 2012,45(3):226-32.

30.Wu X, Xu X, Gu R, Wang Z, Chen H, Xu K, Zhang M, Hutton J, Yang T.Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays.Autoimmunity. 2012,45(2):176-85.

31.Gu Y, Zhang M, Chen H, Wang Z, Xing C, Yang H, Xu X, Liu Y, Zhou Z, Yu L, Hutton J, Eisenbarth G, Yang T. Discordant association of islet autoantibodies with high-risk HLA genes in Chinese type 1 diabetes. Diabetes Metab Res Rev. 2011,27(8):899-905.

32.Xu K. Zhang M. Cui D. Fu Y. Qian L. Gu R. Wang M. Shen C. Yu R. Yang T. UCP2 -866G/A and Ala55Val, and UCP3 -55C/T polymorphisms in association with type 2 diabetes susceptibility: a meta-analysis study. Diabetologia. 2011,54(9):2315-24.

33.Xu K,Zha M,Wu X,Yu Z,Yu R,Xu X,Chen H,Yang T, Association between rs13266634 C/T polymorphisms of solute carrier family 30 member 8 (SLC30A8) and type 2 diabetes, impaired glucose tolerance, type 1 diabetes-A meta-analysis. Diabetes Res Clin Pract.2011,91(2):195-202.