简介：

 韩晓，男，1962年出生，江苏省南京市人，教授，博士生导师。主持或参与科技部973项目课题3项、“重大新药创制”科技重大专项1项、国家自然科学基金重点项目1项、国际（地区）合作与交流项目1项、面上项目3项、省级课题3项，已结题项目均获得较好的评价；在SCI收录期刊杂志上发表文章80余篇，代表性论文发表在PNAS、Diabetes、Diabetologia、Endocrinology 等专业高水平杂志上。获得省部级奖励1项，2010年江苏省有突出贡献的中青年专家和江苏省第三期“333工程”突出贡献奖，江苏省第四期333高层次人才培养工程第二层次培养对象。获得授权的发明专利3项。

现任职务：

江苏省人类功能基因组学重点实验室主任

专业方向：

生物化学与分子生物学

科研方向：

糖尿病发病机制研究，关注胰岛β细胞功能和数量的改变与2型糖尿病的关系。

主要学术兼职：

中国细胞生物学学会理事，江苏省免疫学会理事，江苏省医学科研管理学会理事，美国内分泌学会会员。担任The International Journal of Biochemistry & Cell Biology杂志（IF：4.634）、Journal of Biomedical Research、医学分子生物学杂志编委。

近年承担课题情况

转录因子Ets-1介导2型糖尿病胰岛β细胞去分化与转分化的作用与机制研究，国家自然科学基金重点项目，2019年1月-2023年12月，294万元，主持；

SAD-A介导的mTORC1信号在代谢性疾病中调控胰岛β细胞功能和数量的作用，国家自然科学基金国际（地区）合作研究重点项目，2015年1月-2019年12月，300万元，主持；

营养失衡导致脂代谢紊乱疾病的病理生理学机制与早期干预研究，科技部973项目课题，2012年1月-2016年12月，120万元，课题骨干；

内质网应激与胰岛β细胞凋亡，科技部973项目课题，2010年8月-2015年8月，413万元，主持；

Ets-1在糖尿病胰岛beta细胞功能障碍中的作用研究，国家自然科学基金重点项目，2012年1月-2016年12月，260万元，主持。

近年来发表的主要文章

Sun T, Han X*. Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes. Semin Cell Dev Biol. 2019 Dec 9. pii: S1084-9521(19)30204-6. (IF: 5.46)

Li K, Qiu C, Sun P, Liu DC, Wu TJ, Wang K, Zhou YC, Chang XA, Yin Y, Chen F, Zhu YX, Han X*.Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles, Cell Rep. 2019 Mar 12; 26 (11), 2998-3010.e5. (IF: 7.815)

Liu D, Wang K, Li K, Xu R, Chang X, Zhu Y, Sun P, Han X*.Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis. Cell Death Dis. 2019 Jun 12; 10 (6), 458. (IF: 5.959)

Zhu Y, Sun Y, Zhou Y, Zhang Y, Zhang T, Li Y, You W, Chang X, Yuan L, Han X*. MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis. J Mol Cell Biol. 2019 Sep 19, 11 (9), 747-760. (IF: 4.671)

Wang K, Liu D, Zhang Y, Chang X, Xu R, Pang J, Li K, Sun P, Zhu Y, Han X*. SAD-A, a downstream mediator of GLP-1 signaling, promotes the phosphorylation of Bad S155 to regulate in vitro β-cell functions. Biochem Biophys Res Commun. 2019 Jan 29;509(1):76-81. (IF:2.705)

Huang Q, You W, Li Y, Sun Y, Zhou Y, Zhang Y, Liu D, Zhan S, Zhu Y, Han X*. Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival. Diabetes. 2018 Nov;67(11):2280-2292. (IF: 7.199)

Chen S, Li X, Liu L, Liu C*, Han X*. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB J. 2018 Mar;32(3):1139-1153. (IF: 5.391)

Zhan S, Wu Y, Sun P, Lin H, Zhu Y, Han X*. Decrease in Circulating Fatty Acids Is Associated with Islet Dysfunction in Chronically Sleep-Restricted Rats. Int J Mol Sci. 2016 Dec 14;17(12). (IF:4.183)

Zhang Y, Mei H, Chang X, Chen F, Zhu Y, Han X*, Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155, J Mol Cell Biol. 2016 Sep 25; 8 (6), 505-517 (IF: 6.459)

Zhang Y, Mei H, Shan W, Shi L, Chang X, Zhu Y, Chen F*, Han X*, Lentinan protects pancreatic β cells from STZ-induced damage, J Cell Mol Med. 2016 Oct;20(10):1803-12. (IF: 4.938)

Li Y, Zhang T, Huang Q, Sun Y, Chang X, Zhang H, Zhu Y*, Han X*, Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise, Endocrine. 2016 May 9; 54 (2), 383-395 (IF: 3.279)

Gao F, Zhang X, Zhou L, Zhou S, Zheng Y, Yu J, Fan W, Zhu Y*, Han X*,Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery, Metabolism. 2016 Feb; 65(2):78-88. (IF: 4.375)

Chen F, Sha M, Wang Y, Wu T, Shan W, Liu J, Zhou W, Zhu Y, Sun Y, Shi Y, Bleich D, Han X*, Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models, Diabetologia. 2016 Feb;59(2):316-24. (IF: 6.206)

Chen F, Liu J, Wang Y, Wu T, Shan W, Zhu Y, Han X*, Aldosterone induces clonal β-cell failure through glucocorticoid receptor, Sci Rep. 2015 Aug 19;5:13215. (IF: 5.228)

Xu B, Chen M, Ji X, Yao M, Mao Z, Zhou K, Xia Y, Han X*, Tang W*, Metabolomic profiles reveal key metabolic changes in heat stress-treated mouse Sertoli cells, Toxicol In Vitro. 2015 Oct;29(7):1745-52. (IF: 3.338)

Wang Y, Lin H, Hao N, Zhu Z, Wang D, Li Y,Chen H, Zhu Y, Han X*, Forkhead box O1 mediates defects in palmitate-inducedinsulin granule exocytosis by downregulation of calcium/calmodulin-dependentserine protein kinase expression in INS-1 cells. Diabetologia. 2015 ; 58(6):1272-81.  (IF: 6.671)

Chen F, Liu J, Wang Y, Wu T, Shan W, Zhu Y, HanX*, Aldosterone induces clonal β-cell failure through glucocorticoidreceptor. Sci Rep. 2015 ; 5: 13215. (IF: 5.578)

Qiao N, Xu C, Zhu YX, Cao Y, Liu DC, Han X*, Ets-1as an early response gene against hypoxia-induced apoptosis in pancreaticβ-cells. Cell Death Dis. 2015 ; 6:e1650. (IF: 5.014)

Wang H, Wang X, Zhu Y, Chen F, Sun Y, Han X*, Increasedandrogen levels in rats impair glucose-stimulated insulin secretion throughdisruption of pancreatic beta cell mitochondrial function, J Steroid BiochemMol Biol. 2015 Nov; 154:254-66. (IF: 3.628）

Zhang Y*, Shi L, Mei H, Zhang J, Zhu Y, Han X*, Zhu D*, Inflamed macrophage microvesicles induce insulin resistance in humanadipocytes. Nutr Metab (Lond). 2015 Jun 6;12:21. (IF: 3.258)

Nie J, Liu X, Lilley BN, Zhang H, Pan YA, KimballSR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X^*,Shi Y^*. SAD-A kinase controls islet β-cell size and functionas a mediator of mTORC1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13857-62.   (IF: 9.737)

Zhu Y, You W, Wang H, Li Y, Qiao N, Shi Y,Zhang C, Bleich D, Han X*, MicroRNA-24/MODY GeneRegulatory Pathway Mediates Pancreatic Beta-Cell Dysfunction. Diabetes.2013 Sep; 62(9):3194-206. (IF: 7.895)

Nie J, Lilley BN, Pan YA, FaruqueO, Liu X, Zhang W, Sanes JR, Han X*, Shi Y*, SAD-A potentiates glucose-stimulated insulin secretion as amediator of glucagon-like peptide 1 response in pancreatic β cells, MolCell Biol. 2013 Jul;33(13):2527-34. (IF: 5.372)

Zhang Q, Zhu Y, Zhou W, Gao L, Yuan L*, HanX*, Secretion Serotonin Receptor 2C and Insulin Secretion, PLoSOne. 2013; 8(1):e54250. （IF: 3.73)

Wang Y, Zhu Y, Gao L, YinH, Xie Z, Wang D, Zhu Z, Han X*, Formononetin attenuates IL-1β-induced apoptosis andNF-κB activation in INS-1 cells, Molecules. 2012 ;17(9):10052-64. (IF: 2.428)

Lu G, Zheng M, Zhu Y, Sha M, Wu Y, HanX*, Selection of peptide inhibitor to matrix metalloproteinase-2 usingphage display and its effects on pancreatic cancer cell lines PANC-1 andCFPAC-1. Int J Biol Sci. 2012; 8(5):650-62.  (IF:3.168)

Lin HY, Yin Y, Zhang JX, Xuan H, Zheng Y, ZhanSS, Zhu YX, Han X*, Identification of direct forkhead box O1targets involved in palmitate-induced apoptosis in clonalinsulin-secreting cells using chromatin immunoprecipitation coupled to DNAselection and ligation, Diabetologia. 2012 ; 55(10):2703-12.  (IF: 6.487)

Nie J, Sun C, Faruque O, Ye G, Li J, Liang Q, Chang Z, Yang W, Han X*, Shi Y*, Synapses ofamphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretionthrough activation of p21-activated kinase (PAK1) in pancreatic β-cells, JBiol Chem. 2012 ;287(31):26435-44.  （IF: 4.651)

Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX,Sun YJ, Han X*, Aberrant activation of liver X receptorsimpairs pancreatic beta cell function through upregulation of sterol regulatoryelement-binding protein 1c in mouse islets and rodent cell lines. Diabetologia. 2012 ;55(6):1733-44.  (IF: 6.487)