苗登顺
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发布人:  发布时间:2014-04-01   动态浏览次数:153


苗登顺,男,1954年出生,江苏省宝应市人,基础医学院特聘教授,博士生导师,江苏省人类功能基因组学重点实验室副主任。硕士研究生毕业于南京医科大学人体解剖学专业,博士研究生毕业于英国sheffield大学临床医学院临床生化与代谢专业。历年来,主持973子课题2项、国家自然科学基金重点项目2项、面上项目1项。在J Clin InvestGenes DevPNASPLoS GeneticsHum Mol GenetJ Bone Mineral ResJ Biol Chem Endocrinology等国际权威期刊上发表SCI论文65篇。获得省部级奖励3项。授权的发明专利1项(排名第1)。

现任职务:南京医科大学基础医学院人体解剖学系学术带头人

专业方向:骨与干细胞生物学

科研方向:1)骨与干细胞生物学(2)衰老与疾病

主要学术兼职:加拿大McGill大学医学系兼职教授。

近年承担课题情况

序号

项目名称

经费

(万元)

起止

时间

本人

职责

项目来源

1

活性维生素D通过调节细胞衰老发挥抗衰老和抗肿瘤双重作用

270

201311-20171231

主持

国家自然科学基金重点项目

2

MSC自我更新与分化信号调控机制

293

201211-20161231

主持

973计划项目课题

3

Bmi1和其它表观遗传学调节分子在介导甲状旁腺素相关肽抗衰老中的作用

45

201011-20131231

主持

国家自然科学基金委中加联合项目

近年来发表的主要文章

序号

论文、专著名称

年份

期刊名称(当年影响因子)

(期)

1

Endogenous Parathyroid Hormone – Related Protein Compensates for the Absence of Parathyroid Hormone in Promoting Bone Accrual In Vivo in a Model of Bone Marrow Ablation.

2013

Journal of Bone and Mineral Research, 6.128

28(9)

1898-911

2

1,25(OH)2D deficiency induces temporomandibular joint osteoarthritis

via secretion of senescence-associated infl- ammatory cytokines

2013

Bone, 3.823

55

239-45

3

Absence of PTHrP Nuclear Localization and Carboxyl Terminus Sequences Leads to Abnormal Brain Development and Function.

2012

PLoS One, 3.73

7(7)

14224-9

4

Correction: Bmi-1 Absence Causes Premature Brain Degeneration.

2012

PLoS One, 3.73

7(2)

23-35

5

Bone marrow ablation demonstrates that excess endogenous parathyroid hormone plays distinct roles in trabecular and cortical bone.

2012

Am J Pathol, 4.522

181(1)

7579-90

6

Abnormal neurogenesis in the dentate gyrus of adult mice lacking 1,25-dihydroxyvitaminD3(1,25-(OH)2D3).

2012

Hippocampus, 5.492

22(3)

1439-1444

7

The Abnormal Phenotypes of Cartilage and Bone in Neonatal Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus and PTH.

2011

PLoS Genetics, 8.694

7(9)

12258-69

8

Zinc Supplementation results in improved therapeutic potential of bone marrow-derived mesenchymal stromal cells in a mouse is chemiclimb model.

2011

Cytotherapy, 3.055

13

2041-2052

9

Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse.

2011

PLoS One, 4.092

6

2433-2441

10

The calcium-sensing receptor mediates bone turnover induced by dietary Calcium and parathyroid hormone in neonates.

2011

J Bone Miner Res, 6.373

26

1057-1071

11

Endogenous PTH Deficiency Impairs Fracture Healing and Impedes the Fracture-Healing  Efficacy of Exogenous PTH (1-34)

2011

PLoS One, 4.092

6

e23060

12

An improved Transplantation strategy for mouse mesenchymal stem cells in an acute myocardial in farction model.

2011

PLoS One, 4.092

6

e21005

13

1,25-dihydroxyvitamin D3Contributesto Regulating Mammary Calcium Transport and Modulates Neonatal Skeletal Growth and Turnover Cooperatively with Calcium.

2011

Am Physiol Endocrinol Metab, 4.746

301

E889-900

14

Impairment of spatial learning and memory in transgenic mice over expressing human fibroblast growthfactor-23.

2011

Brain Res, 2.728

15

1412:9-17.

15

Fibroblast growth factor 23 over expression impacts negatively on dentin mineralization and Dentinogenesis in mice.

2011

Clin Exp Pharmacol Physiol, 1.851

38

395-402

16

Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1null mice.

2010

J Bone Miner Res, 7.056

25

640-652

17

Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extra cellular calcium and/or phosphorus.

2010

Am J Physiol Endocrinol Metab, 4.686

299

E928-935

18

Alterations in phosphorus calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice

2010

Development, 6.898

137

985-992

19

The calcium-sensing receptor and 25-hydroxyvitaminD-1alpha-hydroxylase interact to modulate Skeletal growth and bone turnover.

2010

J Bone Miner Res, 7.056

25

1627-1636