韩晓
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发布人:gnjyadmin  发布时间:2016-09-30   动态浏览次数:297

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简介:

韩晓,男,1962年出生,江苏省南京市人,教授,博士生导师,博士研究生毕业于德国维尔茨堡大学病毒与免疫学专业。2003年回国以来,主持或参与科技部973项目课题3项、“重大新药创制”科技重大专项1项、国家自然科学基金重点项目1项、国际(地区)合作与交流项目1项、面上项目3项、省级课题3项,已结题项目均获得较好的评价;在SCI收录期刊杂志上发表文章80余篇,代表性论文发表在PNASDiabetes、Diabetologia、Endocrinology 等专业高水平杂志上。获得省部级奖励1项,2010年江苏省有突出贡献的中青年专家和江苏省第三期“333工程”突出贡献奖,江苏省第四期333高层次人才培养工程第二层次培养对象。获得授权的发明专利3项。

现任职务:

南京医科大学基础医学院院长,江苏省人类功能基因组学重点实验室主任

专业方向:

生物化学与分子生物学

科研方向:

糖尿病发病机制研究,关注胰岛β细胞功能和数量的改变与2型糖尿病的关系。

主要学术兼职:

中国细胞生物学学会理事,江苏省免疫学会理事,江苏省医学科研管理学会理事,美国内分泌学会会员。担任The International Journal of Biochemistry & Cell Biology杂志(IF:4.634)、Journal of Biomedical Research、医学分子生物学杂志编委。

近年承担课题情况

1.SAD-A介导的mTORC1信号在代谢性疾病中调控胰岛β细胞功能和数量的作用,国家自然科学基金国际(地区)合作研究重点项目,2015年1月-2019年12月,300万元,主持;

2. 营养失衡导致脂代谢紊乱疾病的病理生理学机制与早期干预研究,科技部973项目课题,2012年1月-2016年12月,120万元,课题骨干;

3. 内质网应激与胰岛β细胞凋亡,科技部973项目课题,2010年8月-2015年8月,413万元,主持;

4. Ets-1在糖尿病胰岛beta细胞功能障碍中的作用研究,国家自然科学基金重点项目,2012年1月-2016年12月,260万元,主持。

近年来发表的主要文章

1. Zhang Y, Mei H, Chang X, Chen F, Zhu Y, Han X*, Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155, J Mol Cell Biol. 2016 Sep 25. pii: mjw040. [Epub ahead of print] (IF: 6.459)

2. Zhang Y, Mei H, Shan W, Shi L, Chang X, Zhu Y, Chen F*, Han X*, Lentinan protects pancreatic β cells from STZ-induced damage, J Cell Mol Med. 2016 Oct;20(10):1803-12. (IF: 4.938)

3. Li Y, Zhang T, Huang Q, Sun Y, Chang X, Zhang H, Zhu Y*, Han X*, Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise, Endocrine. 2016 May 9. [Epub ahead of print] (IF: 3.279)

4. Gao F, Zhang X, Zhou L, Zhou S, Zheng Y, Yu J, Fan W, Zhu Y*, Han X*,Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery, Metabolism. 2016 Feb; 65(2):78-88. (IF: 4.375)

5. Chen F, Sha M, Wang Y, Wu T, Shan W, Liu J, Zhou W, Zhu Y, Sun Y, Shi Y, Bleich D, Han X*, Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models, Diabetologia. 2016 Feb;59(2):316-24. (IF: 6.206)

7. Chen F, Liu J, Wang Y, Wu T, Shan W, Zhu Y, Han X*, Aldosterone induces clonal β-cell failure through glucocorticoid receptor, Sci Rep. 2015 Aug 19;5:13215. (IF: 5.228)

8. Xu B, Chen M, Ji X, Yao M, Mao Z, Zhou K, Xia Y, Han X*, Tang W*, Metabolomic profiles reveal key metabolic changes in heat stress-treated mouse Sertoli cells, Toxicol In Vitro. 2015 Oct;29(7):1745-52. (IF: 3.338)

9. Wang Y, Lin H, Hao N, Zhu Z, Wang D, Li Y,Chen H, Zhu Y, Han X*, Forkhead box O1 mediates defects in palmitate-inducedinsulin granule exocytosis by downregulation of calcium/calmodulin-dependentserine protein kinase expression in INS-1 cells. Diabetologia. 2015 ; 58(6):1272-81.  (IF: 6.671)

10. Chen F, Liu J, Wang Y, Wu T, Shan W, Zhu Y, HanX*, Aldosterone induces clonal β-cell failure through glucocorticoidreceptor. Sci Rep. 2015 ; 5: 13215. (IF: 5.578)

11. Qiao N, Xu C, Zhu YX, Cao Y, Liu DC, Han X*, Ets-1as an early response gene against hypoxia-induced apoptosis in pancreaticβ-cells. Cell Death Dis. 2015 ; 6:e1650. (IF: 5.014)

12. Wang H, Wang X, Zhu Y, Chen F, Sun Y, Han X*, Increasedandrogen levels in rats impair glucose-stimulated insulin secretion throughdisruption of pancreatic beta cell mitochondrial function, J Steroid BiochemMol Biol. 2015 Nov; 154:254-66. (IF: 3.628

13. Zhang Y*, Shi L, Mei H, Zhang J, Zhu Y, Han X*, Zhu D*, Inflamed macrophage microvesicles induce insulin resistance in humanadipocytes. Nutr Metab (Lond). 2015 Jun 6;12:21. (IF: 3.258)

14. Nie J, Liu X, Lilley BN, Zhang H, Pan YA, KimballSR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X*,Shi Y*. SAD-A kinase controls islet β-cell size and functionas a mediator of mTORC1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13857-62.   (IF: 9.737)

15. Zhu Y, You W, Wang H, Li Y, Qiao N, Shi Y,Zhang C, Bleich D, Han X*, MicroRNA-24/MODY GeneRegulatory Pathway Mediates Pancreatic Beta-Cell Dysfunction. Diabetes.2013 Sep; 62(9):3194-206. (IF: 7.895)

16. Nie J, Lilley BN, Pan YA, FaruqueO, Liu X, Zhang W, Sanes JR, Han X*, Shi Y*, SAD-A potentiates glucose-stimulated insulin secretion as amediator of glucagon-like peptide 1 response in pancreatic β cells, MolCell Biol. 2013 Jul;33(13):2527-34. (IF: 5.372)

17. Zhang Q, Zhu Y, Zhou W, Gao L, Yuan L*, HanX*, Secretion Serotonin Receptor 2C and Insulin Secretion, PLoSOne. 2013; 8(1):e54250. IF: 3.73)

18. Wang Y, Zhu Y, Gao L, YinH, Xie Z, Wang D, Zhu Z, Han X*, Formononetin attenuates IL-1β-induced apoptosis andNF-κB activation in INS-1 cells, Molecules. 2012 ;17(9):10052-64. (IF: 2.428)

19. Lu G, Zheng M, Zhu Y, Sha M, Wu Y, HanX*, Selection of peptide inhibitor to matrix metalloproteinase-2 usingphage display and its effects on pancreatic cancer cell lines PANC-1 andCFPAC-1. Int J Biol Sci. 2012; 8(5):650-62.  (IF:3.168)

20. Lin HY, Yin Y, Zhang JX, Xuan H, Zheng Y, ZhanSS, Zhu YX, Han X*, Identification of direct forkhead box O1targets involved in palmitate-induced apoptosis in clonalinsulin-secreting cells using chromatin immunoprecipitation coupled to DNAselection and ligation, Diabetologia. 2012 ; 55(10):2703-12.  (IF: 6.487)

21. Nie J, Sun C, Faruque O, Ye G, Li J, Liang Q, Chang Z, Yang W, Han X*, Shi Y*, Synapses ofamphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretionthrough activation of p21-activated kinase (PAK1) in pancreatic β-cells, JBiol Chem. 2012 ;287(31):26435-44.  IF: 4.651)

22. Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX,Sun YJ, Han X*, Aberrant activation of liver X receptorsimpairs pancreatic beta cell function through upregulation of sterol regulatoryelement-binding protein 1c in mouse islets and rodent cell lines. Diabetologia. 2012 ;55(6):1733-44.  (IF: 6.487)