高威
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发布人:gnjyadmin  发布时间:2016-09-26   动态浏览次数:10



简介:

        高威,女,1979年出生,吉林省舒兰市人。教授,博士生导师。博士研究生毕业于中科院上海生物化学与细胞生物学研究所,后赴美国国立卫生研究院肿瘤研究所(NIH/NCI)接受博士后训练,2015年10月回国。在SCI 收录的期刊上发表论文10余篇,代表论文发表在Nature Communications,  Hepatology,  PNAS等专业高水平杂志上。相关成果多次被NIH/NCI的肿瘤研究中心列为年度突破性进展,相关工作已申请四项国际专利。

专业方向:

细胞生物学及肿瘤的靶向性治疗

科研方向:

(1)肝癌发生的分子机制研究(2)肿瘤的异质性分析(3)嵌合抗原受体(CAR)T细胞治疗

主要学术兼职:

中华医学会医学细胞生物学分会理事

江苏省细胞和发育生物学学会理事

江苏省免疫学会区域与移植免疫专业委员会委员

近年来发表的主要文章

1.Chunguang Wang*, Wei Gao*, Mingqian Feng, Ira Pastan, Mitchell Ho. Construction of an immunotoxin, HN3-mPE24, targeting glypican-3 for liver cancer therapy. (*contributed equally)Oncotarget (2016) doi: 10.18632/oncotarget.10592

2.Wei Gao, Yongmei Xu, Jian Liu & Mitchell Ho. Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate. Scientific Reports(2015) 17;6:26245

3.Wei Gao*, Zhewei Tang*, Yi-Fan Zhang, Mingqian Feng, Min Qian, Dimiter S. Dimitrov, Mitchell Ho. Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis. (*contributed equally) Nature Communications(2015) doi: 10.1038/ncomms7536. 

4.Wei Gao, Heungnam Kim, Mitchell Ho. Human monoclonal antibody targeting the heparan sulfate chains of glypican-3 inhibits HGF-mediated migration and motility of hepatocellular carcinoma cells. PLoS One. (2015) doi: 10.1371/journal.pone.0137664.

5.Wei Gao, Heungnam Kim, Mingqian Feng, Yen Phung, Charles Xavier, Jeffrey S. Rubin, Mitchell Ho at al. Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chaians of glypican-3 for liver cancer therapy. Hepatology(2014) 60(2): 576-87.

6.Feng M, Gao W, Wang R, Chen W, Man YG, Figg WD, Wang XW, Dimitrov DS, Ho M. Targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma. Proc. Natl. Acad. Sci. U.S.A. (2013)110: E1083-91.

7.Wei Gao, Hui Zhu, Jing-Ya Zhang, xue-Jin Zhang, Xue-Jun Zhang, Calcium signaling-induced Smad3 nuclear accumulation induces acetylcholinesterase transcription in apoptotic HeLa cells. Cellular and Molecular Life Sciences.66 (2009) 2181-2193.

8. Hui Zhu*, W. Gao*,Y.F. Shi, X.J. Zhang, The CCAAT-binding factor CBF/NF-Y regulates the human acetylcholinesterase promoter activity during calcium ionophore A23187-induced cell apoptosis, Biochimica et biophysica acta1770 (2007) 1475-1482.(*contribuhted equally)