王雪融
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发布人:gnjyadmin  发布时间:2016-03-23   动态浏览次数:20



简介

      王雪融,女,19742月出生,博士。南京医科大学基础医学院药理学系教授,硕士生导师。2005年至2009年于美国爱默蕾大学做博士后和研究助理,主要研究抗肿瘤靶向治疗药物的作用机制和耐药机制,肿瘤转移的分子机制以及肿瘤代谢,力图找到药物作用的新靶点和提出新的治疗策略,从而增强药物的抗肿瘤作用。


研究方向:

  肿瘤药理学和分子药理学


主持课题:

1.国家自然科学基金“Glibenclamide通过靶向SUR1-p70S6K调控细胞代谢酶表达抑制非小细胞肺癌作用机制的研究(81473241)(2015-2018)”。

2.国家自然科学基金“IRS-1在头颈部鳞状上皮癌转移中作用和机制的研究(81172004)(2012-2015

3.国家自然科学基金“eIF4Eerlotinib耐药性中作用和机制的研究(81102458),(2012-2014


近期发表主要论文:

1.Xi Chen, Lingjun Zhu, Zhuo Ma, Geng Sun, Min Li, Sulan Zhai, Ping Li, Xuerong Wang. Oncogenic miR-9 is a target of erlotinib in NSCLCs. Scientific Reports. 2015 Nov; 5: 17031.

2.Meijuan Zou, Chen Hu, Qidong You, Aixia Zhang, Xuerong Wang(共同通讯), Qinglong Guo. Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway. Molecular Carcinogenesis. 2015 Nov; 54(11): 1363-1375.

3.Yikun Li, Xuerong Wang(共同第一作者), Ping Yue, Hui Tao, Suresh S. Ramalingam, Taofeek K. Owonikoko, Xingming Deng, Ya Wang, Haian Fu, Fadlo R. Khuri, Shi-Yong Sun. Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation. The journal of Biological Chemistry. 2013 May 10; 288(19): 13215-24.

4.Wenbin Huang, Li Yang, Song Liang, Dongxiao Liu, Xi Chen, Zhuo Ma, Sulan Zhai, Ping Li, Xuerong Wang. AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancer. Digestive Diseases and Sciences. 2013 Oct; 58(10): 2873-80.

5.Zhuo Ma, Lingjun Zhu, Xuan Luo, Sulan Zhai, Ping Li, Xuerong Wang. Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells. Cancer Biology and Therapy. 2012 Sep; 13(11): 1009-1017.

6.Nannan Liu, Qingmin Sun, Jie Chen, Jiaqi Li, Ying Zeng, Sulian Zhai, Ping Li, Bin Wang, Xuerong Wang. MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-κB1 pathway.  Oncology Reports. 2012 Sep; 28(3): 961-968.

7.Xuan Luo, Songqing Fan, Wenbin Huang, Sulan Zhai, Zhuo Ma, Ping Li, Shi-Yong Sun,Xuerong Wang. Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma. Oncology Reports. 2012; 28: 659-667.

8.Song Liang, Song Liang, Renhua Guo, Zhihong Zhang, Dongxiao Liu, Hao Xu, Zekuan Xu, Xuerong Wang(共同通讯作者), Li Yang. Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth. Oncology Reports. 2013 Jun; 29(6): 2422-30.

9.Jie Chen, Nan-Nan Liu, Jia-Qi Li, Li Yang, Ying Zeng, Xiao-Mei Zhao, Lin-Lin Xu, Xuan Luo, Bin Wang, Xue-Rong Wang(通讯作者). Association between ITGA2 C807T polymorphism and gastric cancer risk. World Journal of Gastroenterology. 2011 June 21; 17(23): 2860-2866.

10.Jia-Qi Li, Jie Chen, Nan-Nan Liu, Li Yang, Ying Zeng, Bin Wang, Xue-Rong Wang(通讯作者). Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer. World Journal of Gastroenterology. 2011 April 28; 17(16): 2131-2136.