孙玉洁
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发布人:gnjyadmin  发布时间:2019-06-28   动态浏览次数:814

孙玉洁




        1996年在德国维尔茨堡大学人类遗传所获理学博士学位,同年赴美国洛杉矶City of Hope National Medical Center研究所工作,2003年回国工作,同期被聘为南京医科大学特聘教授、细胞生物学和医学遗传学系主任。

       主要研究方向:(1)增强子元件的调控功能、分子机制及遗传变异的肿瘤生物学效应;(2)肿瘤耐药的分子生物学和表观遗传学机制。回国以来主持国家自然科学基金面上项目和重大研究计划培育项目、科技部973项目课题江苏省重点招标项目等多项科研项目,国际学术期刊发表学术论文40余篇。 获江苏省科学技术进步二等奖一项,国家专利三项。 

        现担任中华医学会医学细胞生物学会副会长,中国遗传学会理事中国遗传学会表观遗传专业委员会委员,江苏省遗传学会副会长,中国细胞生物学会医学细胞学分会常委,中国转化医学联盟常务理事和江苏省医学会委员等学术兼职。

发表的主要文章

1. Lipei  Shao, Xianglin Zuo, Yin Yang, Yu Zhang, Nan Yang , Bin Shen,  Jianying Wang, Xuchun Wang, Ruilei , Guangfu Jin, Dawei Yu, Yuan Chen, Luan Sun , Zhen Li, Qiaofen Fu, Zhibin Hu, Xiao Han, Xin Song*, Hongbin Shen*, Yujie Sun*. The inherited variations of a p53-responsive-enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression. Genome Biology, 2019 May 24. doi: 10.1186/s13059-019-1696-1

2. Si X, Liu Y, Lv J, Ding H, Zhang XA, Shao L, Yang N, Cheng H, Sun L, Zhu D, Yang Y, Li A, Han X, Sun Y*, ERα propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells. Oncotarget, 2016 Apr 12; 7(15):20966-80.

3. Shi JF, Yang N, Ding HJ, Zhang JX, Hu ML, Leng Y, Han X, Sun YJ*, ERα directly activated the MDR1 transcription to increase paclitaxel-resistance of ERα-positive breast cancer cells in vitro and in vivo, Int J Biochem Cell Biol. 2014 Apr 28;53C:35-45.

4. Gong F, Sun L, Wang Z, Shi J, Li W, Wang S, Han X, Sun Y*. The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR. Nucleic Acids Res. 2011 Jun 1; 39(11): 4640-4652.

5. Wang T, Lv JH, Zhang XF, Li CJ, Han X, Sun YJ*. Tissue inhibitor of metalloproteinase-1 protects MCF-7 breast cancer cells from paclitaxel-induced apoptosis by decreasing the stability of cyclin B1. Int J Cancer. 2010 Jan 15; 126(2):362-70.

6. Ma C, Zhang J, Durrin LK, Lv J, Zhu D, Han X, Sun Y*. The BCL2 major breakpoint region (mbr) regulates gene expression. Oncogene. 2007 Apr 19; 26(18):2649-57.

7. Sun Y, Durrin LK, Krontiris TG. Specific interaction of PML bodies with the TP53 locus in Jurkat interphase nuclei.Genomics. 2003 Aug;82(2):250-2.

8. Sun Y, Wyatt RT, Bigley A, Krontiris TG. Expression and replication timing patterns of wildtype and translocated BCL2 genes. Genomics. 2001 Apr 15; 73(2):161-70.

9. Sun YJ, Baumer A. Nonrandom X inactivation and selection of fragile X full mutation in fetal fibroblasts. Am J Med Genet. 1999 Sep 10; 86(2):162-4.

10. Seyschab H, Friedl R, Sun Y, Schindler D, Hoehn H, Hentze S, Schroeder-Kurth T. Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia.Blood. 1995 Apr 15;85(8):2233-7.

11. Seyschab H, Bretzel G, Friedl R, Schindler D, Sun Y, Hoehn H.Modulation of the spontaneous G2 phase blockage in Fanconi anemia cells by caffeine: differences from cells arrested by X-irradiation.Mutat Res. 1994 Jul 16;308(2):149-57.

12. Seyschab H, Sun Y, Friedl R, Schindler D, Hoehn H. G2 phase cell cycle disturbance as a manifestation of genetic cell damage.Hum Genet. 1993 Aug;92(1):61-8